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NIA–Reagan cri-teria (The National Institute on Aging, 1997), proposedin 1997, made a couple of important changes, includingincorporation of NFT—using Braak score (Braak andBraak, 1991), and included plaque estimates withoutregard to age, to allow for probability statements of thelikelihood that dementia occurs as a result of AD (high,intermediate, low).

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